Hypoxia is important in the biology and aggression of human glial brain tumors.

@article{Evans2004HypoxiaII,
  title={Hypoxia is important in the biology and aggression of human glial brain tumors.},
  author={Sydney M Evans and Kevin D. Judy and Isolde Dunphy and W. Timothy Jenkins and Wei-ting Hwang and Peter T. Nelson and Robert A. Lustig and Kevin W. Jenkins and Deirdre P Magarelli and Stephen M. Hahn and Ruth A Collins and Michael S Grady and Cameron J. Koch},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 24},
  pages={8177-84}
}
We investigated whether increasing levels of tissue hypoxia, measured by the binding of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] or by Eppendorf needle electrodes, were associated with tumor aggressiveness in patients with previously untreated glial brain tumors. We hypothesized that more extensive and severe hypoxia would be present in tumor cells from patients bearing more clinically aggressive tumors. Hypoxia was measured with the 2-nitroimidazole imaging… CONTINUE READING