Hypoxia is a key regulator of limbal epithelial stem cell growth and differentiation.

@article{Bath2013HypoxiaIA,
  title={Hypoxia is a key regulator of limbal epithelial stem cell growth and differentiation.},
  author={Chris Bath and Sufang Yang and Danson V Muttuvelu and Trine Fink and Jeppe Emmersen and Henrik Vorum and Jesper {\O}stergaard Hjortdal and Vladimir Zachar},
  journal={Stem cell research},
  year={2013},
  volume={10 3},
  pages={
          349-60
        }
}
The aim of this study was to determine whether the growth and differentiation of limbal epithelial stem cell cultures could be controlled through manipulation of the oxygen tension. Limbal epithelial cells were isolated from corneoscleral disks, and cultured using either feeder cells in a growth medium supplemented with serum (3T3 system) or without feeder cells in a dedicated serum-free medium (EpiLife). During the culture, the cells were maintained either at ambient oxygen tension (20%) or at… CONTINUE READING
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