Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms.

@article{McQuillan1994HypoxiaIE,
  title={Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms.},
  author={L P McQuillan and Gordon K. Leung and Philip A. Marsden and Sandra K. Kostyk and Stella Kourembanas},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 2},
  pages={H1921-7}
}
Normal blood vessel tone is maintained by a balance of vasoconstrictors and vasodilators produced by endothelial cells in the vasculature. Nitric oxide (NO) is a potent vasodilator that causes vascular smooth muscle cell relaxation by elevating intracellular guanosine 3',5'-cyclic monophosphate (cGMP) levels. The physiological mechanisms regulating NO production in the vasculature are not completely understood. We report here that production of this vasodilator by vascular endothelial cells can… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 149 extracted citations

Similar Papers

Loading similar papers…