Hypoxia inhibits TRAIL-induced tumor cell apoptosis: Involvement of lysosomal cathepsins

@article{Nagaraj2006HypoxiaIT,
  title={Hypoxia inhibits TRAIL-induced tumor cell apoptosis: Involvement of lysosomal cathepsins},
  author={Nagathihalli S. Nagaraj and N Vigneswaran and Wolfgang Zacharias},
  journal={Apoptosis},
  year={2006},
  volume={12},
  pages={125-139}
}
Tumor hypoxia interferes with the efficacy of chemotherapy, radiotherapy, and tumor necrosis factor-α. TRAIL (tumor necrosis factor-related apoptosis inducing ligand) is a potent apoptosis inducer that limits tumor growth without damaging normal cells and tissues in vivo. We present evidence for a central role of lysosomal cathepsins in hypoxia and/or TRAIL-induced cell death in oral squamous cell carcinoma (OSCC) cells. Hypoxia or TRAIL-induced activation of cathepsins (B, D and L), caspases… CONTINUE READING

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