Hypoxia-inducible transcription factors and their role in renal disease.

@article{Eckardt2007HypoxiainducibleTF,
  title={Hypoxia-inducible transcription factors and their role in renal disease.},
  author={Karl Eckardt and Wanja Michael Bernhardt and Carsten Willam and Michael Sean Wiesener},
  journal={Seminars in nephrology},
  year={2007},
  volume={27 3},
  pages={
          363-72
        }
}
The 2 hypoxia inducible factors (HIF)-1alpha and HIF-2alpha are key mediators of cellular adaptation to hypoxia. They show a specific distribution pattern and possibly have complementary transcriptional targets in the kidney: HIF-1alpha is found mainly in tubular and HIF-2alpha in peritubular interstitial, endothelial, and glomerular cells. Both isoforms are regulated by oxygen-dependent hydroxylation of specific amino acid residues, which determines protein stability and transcriptional… CONTINUE READING
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