Hypoxia-inducible regulation of placental BOK expression.

@article{Luo2014HypoxiainducibleRO,
  title={Hypoxia-inducible regulation of placental BOK expression.},
  author={Daochun Luo and Isabella Caniggia and Martin Post},
  journal={The Biochemical journal},
  year={2014},
  volume={461 3},
  pages={
          391-402
        }
}
BOK (BCL-2-related ovarian killer) is a member of the pro-apoptotic BCL-2 family that is highly expressed in the human placenta. BOK excess causes increased trophoblast autophagy and apoptosis in pre-eclampsia, a pathological condition of hypoxia and oxidative stress. In the present study, we identified an HRE (hypoxia-response element) at the junction of exon-1 and intron-1 (+229 to +279) in the human BOK gene, as well as an antisense transcript driven by a promoter located in intron-2. The… 
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Increased CER augments MF via a mechanism involving BOK, and this may contribute to increased cell death in PE.
The Multifaceted Roles of the BCL-2 Family Member BOK
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In this review, apoptotic- and non–apoptotic-related functions of BOK are summarized and discussed, its regulation as well as its physiological and pathophysiological roles are discussed.
Cell death mechanisms and their roles in pregnancy related disorders.
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The current knowledge and open questions about this paradoxical protein are compiled with a special focus on its structural features as the key aspect to understand BOK biological functions.
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It is indicated that embryos derived from different production techniques have varied in vitro development to the blastocyst stage, and they also affect the transcription level of corresponding genes, such as imprinted genes, which will help future research on these genes and molecular-assisted breeding for pig parthenotes.
Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity
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This review focuses on elaborating on and summarizing the characteristics of ASPs to extend knowledge about the mechanisms of antisense transcript initiation.
Effect of maternal omega-3 fatty acids and vitamin E supplementation on placental apoptotic markers in rat model of early and late onset preeclampsia.
PLANTAS MEDICINAIS, FITOTERÁPICOS E/OU NUTRACÊUTICOS UTILIZADOS NO CONTROLE DA OBESIDADE

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