Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy.

@article{Togashi2005HypoxiainducibleP2,
  title={Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy.},
  author={Akira Togashi and Toyomasa Katagiri and Shingo Ashida and Tomoaki Fujioka and Osamu Maruyama and Yoshiaki Wakumoto and Yoshiro Sakamoto and Makoto Fujime and Yoshio Kawachi and Taro Shuin and Yusuke Nakamura},
  journal={Cancer research},
  year={2005},
  volume={65 11},
  pages={4817-26}
}
To identify molecules to serve as diagnostic markers for renal cell carcinoma (RCC) and as targets for novel therapeutic drugs, we investigated genome-wide expression profiles of RCCs using a cDNA microarray. We subsequently confirmed that hypoxia-inducible protein-2 (HIG2) was expressed exclusively in RCCs and fetal kidney. Induction of HIG2 cDNA into COS7 cells led to secretion of the gene product into culture medium and resulted in enhancement of cell growth. Small interfering RNA… CONTINUE READING

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