Hypoxia inducible factors regulate filaggrin expression and epidermal barrier function

@inproceedings{Wong2015HypoxiaIF,
  title={Hypoxia inducible factors regulate filaggrin expression and epidermal barrier function},
  author={Waihay J. Wong and Theresa R. Richardson and John T Seykora and George Cotsarelis and M Celeste Simon},
  booktitle={The Journal of investigative dermatology},
  year={2015}
}
A functional epidermal skin barrier requires the formation of a cornified envelope from terminally differentiating keratinocytes. During this process, multiple genetic and environmental signals coordinately regulate protein expression and tissue differentiation. Here we describe a critical role for hypoxia-inducible factors (HIFs) in the regulation of filaggrin expression and skin barrier formation. Similar to other mammalian tissues, fetal epidermis in mice is normally O2 deprived… CONTINUE READING