Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.

Abstract

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic… (More)
DOI: 10.1016/j.jhep.2014.08.025

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@article{Wilson2014HypoxiaIF, title={Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.}, author={Garrick K. Wilson and Daniel A Tennant and Marc Ringelhan}, journal={Journal of hepatology}, year={2014}, volume={61 6}, pages={1397-406} }