Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.

@article{Wilson2014HypoxiaIF,
  title={Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.},
  author={Garrick K. Wilson and Daniel A Tennant and Jane A McKeating},
  journal={Journal of hepatology},
  year={2014},
  volume={61 6},
  pages={1397-406}
}
Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies… CONTINUE READING
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Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions

  • G. K. Wilson, D. A. Tennant, J. A. McKeating
  • Journal of Hepatology
  • 2014

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