Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.

@article{Farha2011HypoxiainducibleFI,
  title={Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.},
  author={S. A. Abo Farha and Kewal Asosingh and Weiling Xu and Jacqueline Sharp and Deepa George and Suzy A. A. Comhair and Margaret J Park and Weihong Tang and James E Loyd and Karl S. Theil and Raymond Tubbs and E D Hsi and Alan Eli Lichtin and Serpil C. Erzurum},
  journal={Blood},
  year={2011},
  volume={117 13},
  pages={3485-93}
}
Pulmonary arterial hypertension (PAH) is a proliferative vasculopathy characterized by high circulating CD34(+)CD133(+) proangiogenic progenitors, and endothelial cells that have pathologic expression of hypoxia-inducible factor 1 α (HIF-1α). Here, CD34(+)CD133(+) progenitor cell numbers are shown to be higher in PAH bone marrow, blood, and pulmonary arteries than in healthy controls. The HIF-inducible myeloid-activating factors erythropoietin, stem cell factor (SCF), and hepatocyte growth… CONTINUE READING