Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.

@article{Wang2014HypoxiainducibleFA,
  title={Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.},
  author={Ting Wang and Daniele M Gilkes and Naoharu Takano and Lisha Xiang and Weibo Luo and Corey J. Bishop and Pallavi Chaturvedi and Jordan J Green and Gregg L Semenza},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 31},
  pages={E3234-42}
}
Extracellular vesicles such as exosomes and microvesicles (MVs) are shed by cancer cells, are detected in the plasma of cancer patients, and promote cancer progression, but the molecular mechanisms regulating their production are not well understood. Intratumoral hypoxia is common in advanced breast cancers and is associated with an increased risk of metastasis and patient mortality that is mediated in part by the activation of hypoxia-inducible factors (HIFs). In this paper, we report that… CONTINUE READING
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