Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.

@article{Beasley2002HypoxiainducibleFH,
  title={Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.},
  author={Nigel J. P. Beasley and R. Leek and Mohammed Alam and Helen Turley and Graham J. Cox and Kevin C. Gatter and Peter Millard and Sue Fuggle and Adrian L. Harris},
  journal={Cancer research},
  year={2002},
  volume={62 9},
  pages={2493-7}
}
Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear transcription factors that regulate the cellular response to hypoxia and are important for solid tumor growth and survival. Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013). On… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

Similar Papers

Loading similar papers…