Hypoxia-inducible factor signalling mechanisms in the central nervous system.

  title={Hypoxia-inducible factor signalling mechanisms in the central nervous system.},
  author={Alan E Corcoran and John J. O'Connor},
  journal={Acta physiologica},
  volume={208 4},
In the CNS, neurones are highly sensitive to the availability of oxygen. In conditions where oxygen availability is decreased, neuronal function can be altered, leading to injury and cell death. Hypoxia has been implicated in a number of central nervous system pathologies including stroke, head trauma and neurodegenerative diseases. Cellular responses to oxygen deprivation are complex and result in activation of short- and long-term mechanisms to conserve energy and protect cells. Failure of… CONTINUE READING


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