Hypoxia-inducible factor signalling mechanisms in the central nervous system.

@article{Corcoran2013HypoxiainducibleFS,
  title={Hypoxia-inducible factor signalling mechanisms in the central nervous system.},
  author={Alan E Corcoran and John J. O'Connor},
  journal={Acta physiologica},
  year={2013},
  volume={208 4},
  pages={298-310}
}
In the CNS, neurones are highly sensitive to the availability of oxygen. In conditions where oxygen availability is decreased, neuronal function can be altered, leading to injury and cell death. Hypoxia has been implicated in a number of central nervous system pathologies including stroke, head trauma and neurodegenerative diseases. Cellular responses to oxygen deprivation are complex and result in activation of short- and long-term mechanisms to conserve energy and protect cells. Failure of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

The paracrine effect of cobalt chloride on BMSCs during cognitive function rescue in the HIBD rat.

Behavioural brain research • 2017
View 10 Excerpts
Highly Influenced

Neurotransmitter Interactions and Cognitive Function

Advances in Experimental Medicine and Biology • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 113 references

Hypoxia - inducible factor prolyl 4 - hydroxylase inhibition . A target for neuroprotection in the central nervous system

I. Silver, M. Erecinska
J Biol Chem • 1998
View 1 Excerpt
Highly Influenced

A screen for inducers of p 21 waf 1 / cip 1 identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties

T. C. Ma, B. Langley, +6 authors R. R. Ratan
Neurobiol Dis • 2013
View 1 Excerpt

9 receptor activity in a pertussis toxin - sensitive manner during normoxia but not anoxia in turtle cortical neurons

P. Ghose, J. A. Powell-Coffman
2012

Similar Papers

Loading similar papers…