Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

@article{Speer2013HypoxiainducibleFP,
  title={Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.},
  author={Rachel E Speer and Saravanan S. Karuppagounder and Manuela Basso and Sama F. Sleiman and Amit Kumar and David Ford Manager Susan Brand and Natalya A. Smirnova and Irina G. Gazaryan and Soah J. Khim and Rajiv R Ratan},
  journal={Free radical biology & medicine},
  year={2013},
  volume={62},
  pages={
          26-36
        }
}
Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for these conditions have historically had poor success in translating from bench to bedside. Hypoxia-inducible factor (HIF)-1α mediates a broad, evolutionarily conserved, endogenous adaptive program to hypoxia, and manipulation of components of the HIF pathway is neuroprotective… CONTINUE READING