Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.

@article{Kobayashi2017HypoxiainducibleFP,
  title={Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.},
  author={Hanako Kobayashi and Jiao Liu and Andr{\'e}s A Urrutia and Mikhail Burmakin and Ken J Ishii and Malini Rajan and Olena Davidoff and Zubaida Saifudeen and Volker H Haase},
  journal={Kidney international},
  year={2017},
  volume={92 6},
  pages={
          1370-1383
        }
}
Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducible factor pathway, which is regulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3. In the adult kidney, PHD oxygen sensors are differentially expressed in… CONTINUE READING