Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.

@article{MoroteGarcia2009HypoxiainducibleFR,
  title={Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.},
  author={Julio C{\'e}sar Morote-Garcia and Peter Rosenberger and Nicole M. I. Nivillac and Imogen R. Coe and Holger K. Eltzschig},
  journal={Gastroenterology},
  year={2009},
  volume={136 2},
  pages={607-18}
}
BACKGROUND & AIMS The surface of the intestinal mucosa is particularly prone to hypoxia-induced inflammation. Previous studies implicated signaling via extracellular adenosine in endogenous attenuation of intestinal inflammation; we investigated whether epithelial adenosine transport could reduce hypoxia-induced inflammation of the mucosa. METHODS We performed in vitro studies of epithelial adenosine uptake and nucleoside transport using cultured epithelial cells. In vivo studies of ambient… CONTINUE READING
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