Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress.

@article{Witt2005HypoxiainducibleFA,
  title={Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress.},
  author={Ken A. Witt and Karen S Mark and Jason Delwyn Huber and Thomas P Davis},
  journal={Journal of neurochemistry},
  year={2005},
  volume={92 1},
  pages={
          203-14
        }
}
This investigation focuses on transcription factor involvement in blood-brain barrier (BBB) endothelial cell-induced alterations under conditions of hypoxia and post-hypoxia/reoxygenation (H/R), using established in vivo/ex vivo and in vitro BBB models. Protein/DNA array analyses revealed a correlation in key transcription factor activation during hypoxia and H/R, including NFkappaB and hypoxia-inducible factor (HIF)1. Electrophoretic mobility shift assays confirmed NFkappaB and HIF1 binding… CONTINUE READING
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