Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation.

  title={Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation.},
  author={Misaki Hatanaka and Shigeki Shimba and Motoharu Sakaue and Yukihiro Kondo and Hiroyuki Kagechika and Koichi Kokame and Toshiyuki Miyata and Shuntaro Hara},
  journal={Biological & pharmaceutical bulletin},
  volume={32 7},
Hypoxia-inducible factor (HIF) is a heterodimer composed of HIF-alpha and -beta, and to date, three HIF-alpha subunits, HIF-1alpha, -2alpha, and -3alpha, have been identified. Among these HIF-alpha subunits, HIF-1alpha represses peroxisome proliferator activator gamma2 gene expression and then inhibits adipogenesis, and HIF-2alpha is induced during adipose differentiation and functions as a positive regulator of adipogenesis. We here found that like HIF-2alpha, HIF-3alpha was induced during 3T3… CONTINUE READING

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