Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

  title={Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction},
  author={Siyoung Yang and Jonghwan Kim and Je-Hwang Ryu and Hwanhee Oh and Churl Hong Chun and Byoung Ju Kim and Byoung-Hyun Min and Jang-Soo Chun},
  journal={Nature Medicine},
Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors. Here, we show that hypoxia-inducible factor-2α (HIF-2α, encoded by EPAS1) is a catabolic transcription factor in the osteoarthritic process. HIF-2α directly induces the expression in chondrocytes of genes encoding catabolic factors, including matrix metalloproteinases (MMP1, MMP3, MMP9, MMP12 and MMP13), aggrecanase-1 (ADAMTS4), nitric oxide synthase-2 (NOS2) and prostaglandin-endoperoxide… CONTINUE READING
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