Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.

@article{Chin2007HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.},
  author={Beek Yoke Chin and Ge Ning Jiang and Barbara Wegiel and Hong I Jun Wang and Theresa Macdonald and Xu Zhang and David G. Gallo and Eva Cszimadia and Fritz Heintz Bach and Patty J Lee and Leo E Otterbein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 12},
  pages={5109-14}
}
The most salient feature of carbon monoxide (CO)-mediated cytoprotection is the suppression of inflammation and cell death. One of the important cellular targets of CO is the macrophage (mphi). Many studies have shown that exposure of mphi to CO results in the generation of an antiinflammatory phenotype; however, these reports have ignored the effect of CO alone on the cell before stimulation. Most investigations have focused on the actions of CO in modulating the response to noxious stimuli… CONTINUE READING
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