Hypoxia-inducible factor-1alpha regulates matrix metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells.

@article{Lin2008HypoxiainducibleFR,
  title={Hypoxia-inducible factor-1alpha regulates matrix metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells.},
  author={Jiunn-Liang Lin and Ming Jen Wang and Donching Lee and C T Liang and Shankung Lin},
  journal={FEBS letters},
  year={2008},
  volume={582 17},
  pages={2615-9}
}
We examined the mRNA levels of hypoxia-inducible factor-1alpha (HIF-1alpha) in bone marrow mesenchymal stem cells (bmMSCs) of eight osteoarthritis patients. BmMSC-1, expressing higher HIF-1alpha mRNA and protein than bmMSC-5, elicited higher matrix metalloproteinase-1 (MMP1) activity and stronger invasive capacity. In vitro invasion assays and quantitative PCR analyses showed that targeted inhibition of HIF-1alpha in bmMSC-1 decreased its invasion and expressions of MMP1 and MMP3, whereas… CONTINUE READING
22 Citations
17 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

Hypoxia-inducible factor 1a regulates lung adenocarcinoma cell invasion

  • Shyu, K.-G, +5 authors S. Lin
  • Exp. Cell Res
  • 2007
2 Excerpts

The role of hypoxia inducible factor 1 in hypoxia induced apoptosis

  • A. E. Greijer, E.V.D. Wall
  • J. Clin. Pathol
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…