• Biology, Medicine
  • Published in
    The Journal of clinical…
    2010
  • DOI:10.1172/JCI35846

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.

@article{Cheng2010HypoxiainducibleFR,
  title={Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.},
  author={Kim Cheng and Kenneth Ho and Rebecca M. Stokes and Christopher Thomas Scott and Sue Mei Lau and Wayne John Hawthorne and Philip J. O'connell and Thomas Loudovaris and Thomas W H Kay and Rohit N. Kulkarni and Terumasa Okada and Xiaohui L Wang and Sun Hee Yim and Yatrik M. Shah and Shane T Grey and Andrew V. Biankin and James G. Kench and D. Ross Laybutt and Frank J. Gonzalez and C. Ronald Kahn and Jenny E Gunton},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 6},
  pages={
          2171-83
        }
}
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1alpha protein are tightly regulated, recent studies suggest that it can be active under normoxic conditions. We hypothesized that HIF-1alpha is required for normal beta cell function and reserve and that dysregulation may contribute to the pathogenesis of type 2 diabetes (T2D). Here we show that HIF-1alpha protein is present at low levels in mouse and human… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 99 CITATIONS, ESTIMATED 56% COVERAGE

Hepatogenous Diabetes: An Underestimated Problem of Liver Cirrhosis

  • Ramesh Kumar
  • Medicine
  • Indian journal of endocrinology and metabolism
  • 2018
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The role of ARNT in liver and myeloid cell function

VIEW 7 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

The role of Npas4 and Rgs2 in the regulation of pancreatic β-cell function

VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

VIEW 4 EXCERPTS
CITES RESULTS
HIGHLY INFLUENCED

Ciclopirox enhances pancreatic islet health by modulating the unfolded protein response in diabetes

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing.

VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019