Hypoxia-inducible factor 1alpha may be a marker for vasculitic neuropathy.

  title={Hypoxia-inducible factor 1alpha may be a marker for vasculitic neuropathy.},
  author={Nobuyuki Oka and Teruaki Kawasaki and Kotaro Mizutani and Hiroshi Sugiyama and Ichiro Akiguchi},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  volume={27 6},
Neuromuscular biopsy is still an essential method for diagnosing vasculitic neuropathy, although its diagnostic sensitivity is at most 60%. Our objective was to examine the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) in peripheral nerves and to evaluate its usefulness in diagnosing vasculitic neuropathy, especially for discrimination from other axonal neuropathies. Forty-one patients with vasculitic neuropathy consisting of 20 definite, 14 probable and seven possible diagnoses… CONTINUE READING