• Medicine
  • Published in Cancer research 2000

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

@article{Ryan2000HypoxiainducibleFI,
  title={Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.},
  author={Heather E. Ryan and Marco Poloni and William McNulty and David Elson and Max Gassmann and Jeffrey Arbeit and R S Johnson},
  journal={Cancer research},
  year={2000},
  volume={60 15},
  pages={
          4010-5
        }
}
Deficiencies in oxygenation are widespread in solid tumors. The transcription factor hypoxia-inducible factor (HIF)-1alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regulation of a number of factors important for solid tumor expansion, including the angiogenic factor vascular endothelial growth factor (VEGF). We have isolated two cell lines nullizygous for HIF-1alpha, one from embryos genetically null for HIF-1alpha, and the other from embryos carrying… CONTINUE READING

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  • Biology, Medicine
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