Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.

@article{Zhang2007HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.},
  author={Xian Zhang and Kun Zhou and Ruishan Wang and Jiankun Cui and Stuart Lipton and F Liao and Huaxi Xu and Yunwu Zhang},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 15},
  pages={10873-80}
}
The incidence of Alzheimer disease (AD) and vascular dementia is greatly increased following cerebral ischemia and stroke in which hypoxic conditions occur in affected brain areas. beta-Amyloid peptide (Abeta), which is derived from the beta-amyloid precursor protein (APP) by sequential proteolytic cleavages from beta-secretase (BACE1) and presenilin-1 (PS1)/gamma-secretase, is widely believed to trigger a cascade of pathological events culminating in AD and vascular dementia. However, a direct… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment

Cellular and Molecular Neurobiology • 2016
View 7 Excerpts
Highly Influenced

Calcium sensing receptor mediated the excessive generation of β-amyloid peptide induced by hypoxia in vivo and in vitro.

Biochemical and biophysical research communications • 2015
View 4 Excerpts
Highly Influenced

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

Neurotoxicity Research • 2013
View 3 Excerpts
Highly Influenced

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation.

Molecular and cellular neurosciences • 2012
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…