Hypoxia-inducible factor-1alpha expression correlates with focal macrophage infiltration, angiogenesis and unfavourable prognosis in urothelial carcinoma.

@article{Chai2008HypoxiainducibleFE,
  title={Hypoxia-inducible factor-1alpha expression correlates with focal macrophage infiltration, angiogenesis and unfavourable prognosis in urothelial carcinoma.},
  author={C Y Chai and W-t Chen and W-C Hung and W-Y Kang and Y-C Huang and Y Su and C Yang},
  journal={Journal of clinical pathology},
  year={2008},
  volume={61 5},
  pages={658-64}
}
BACKGROUND Hypoxia inducible factor (HIF)-1alpha is a critical regulatory protein of cellular response to hypoxia and is closely related to angiogenic process. AIMS To explore the potential role and the prognostic value of HIF-1alpha in urothelial carcinoma (UC). METHODS Clinicopathological and follow-up data on 99 UC cases were reviewed and immunostained for HIF-1alpha, CD68, vascular endothelial growth factor (VEGF) and CD34 antigen. Tumour-associated macrophage (TAM) counts and HIF… CONTINUE READING
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