Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast.

  title={Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast.},
  author={Hirotaka Nishi and Toshihide Nakada and Mitsuyasu Hokamura and Yumi Osakabe and Osamu Itokazu and Lei Huang and Keiichi Isaka},
  volume={145 9},
Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. Intervillous blood flow increases after 10 wk of gestation and results in exposure of trophoblast cells to oxygen. Before this time, low oxygen appears to prevent trophoblast differentiation toward an invasive phenotype. The oxygen-regulated early events of trophoblast differentiation are mediated by TGF-beta3. TGF-beta3 plays a vital role in trophoblast differentiation… CONTINUE READING


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