Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition.

@article{Dang2008HypoxiainducibleFT,
  title={Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition.},
  author={Duyen T. Dang and Sang Young Chun and Kyunghee Burkitt and Masako Abe and Shaowei Chen and Pamela A. Havre and Nicola J. Mabjeesh and Elisabeth Heath and Nicholas John Vogelzang and Marcia Cruz-Correa and Douglas W. Blayney and William D. Ensminger and Brad St. Croix and Nam Dang and Long H Dang},
  journal={Cancer research},
  year={2008},
  volume={68 6},
  pages={1872-80}
}
Antiangiogenic therapy improves survival in patients with advanced stage cancers. Currently, there are no reliable predictors or markers for tumor vessel response to antiangiogenic therapy. To model effective antiangiogenic therapy, we disrupted the VEGF gene in three representative cancer cell lines. HCT116 xenografts had low proportions of endothelial tubes covered by pericytes that stained with alpha-smooth muscle actin (SMA) antibody. Upon disruption of VEGF, HCT116(VEGF-/-) xenografts had… CONTINUE READING