Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.

@article{Sakamoto2014HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.},
  author={Takeharu Sakamoto and Jane S. Weng and Toshiro Hara and Seiko Yoshino and Hiroko Kozuka-Hata and Masaaki Oyama and Motoharu Seiki},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 1},
  pages={30-42}
}
Hypoxia-inducible factor 1 (HIF-1) plays a key role in the cellular adaptation to hypoxia. Although HIF-1 is usually strongly suppressed by posttranslational mechanisms during normoxia, HIF-1 is active and enhances tumorigenicity in malignant tumor cells that express the membrane protease MT1-MMP. The cytoplasmic tail of MT1-MMP, which can bind a HIF-1 suppressor protein called factor inhibiting HIF-1 (FIH-1), promotes inhibition of FIH-1 by Mint3 during normoxia. To explore possible links… CONTINUE READING

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