Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer.

@article{Buechler2003HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer.},
  author={Peter Buechler and Howard A. Reber and Manuela C B{\"u}chler and Shailesh Shrinkante and Markus W. B{\"u}chler and Helmut Friess and Gregg L Semenza and Oscar Joe Hines},
  journal={Pancreas},
  year={2003},
  volume={26 1},
  pages={56-64}
}
INTRODUCTION The microenvironment of low oxygen that is present in human pancreatic cancer in vivo may actively influence tumor growth as well as neovascularization. AIMS To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor specimens. METHODOLOGY Hypoxic regulation of vascular endothelial growth factor (VEGF) was studied by northern blot analysis and enzyme-linked… CONTINUE READING