Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells.

@article{Zhao2010HypoxiaIF,
  title={Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells.},
  author={Xu-Yun Zhao and Ting-Ting Chen and Li Xia and Meng En Guo and Ying Xu and Fei Yu Jiexian Zeng Guangxue Yue and Yi Jiang and Guo-Qiang Chen and Ke-Wen Zhao},
  journal={Carcinogenesis},
  year={2010},
  volume={31 8},
  pages={1367-75}
}
The expression of galectin-1, one of the most important lectins participating in the malignant tumor development, has been shown to be regulated by hypoxia, but its exact mechanism remains elusive. Here, we find that ectopically expressed hypoxia-inducible factor (HIF) 1alpha protein, an oxygen-sensitive subunit of HIF-1 that is a master factor for cellular response to hypoxia, significantly increases galectin-1 expression in both messenger RNA and protein levels in all four colorectal cancer… CONTINUE READING

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