Hypoxia inducible factor-1 improves the actions of positive inotropic agents in stunned cardiac myocytes.

Abstract

1. In the present study, we tested hypothesis that upregulation of hypoxia-inducible factor-1 (HIF-1) would improve the actions of positive inotropic agents in cardiac myocytes after simulated ischaemia-reperfusion (I/R). 2. Hypoxia-inducible factor-1α was upregulated with deferoxamine (150 mg/kg per day for 2 days). Rabbit cardiac myocytes were subjected… (More)
DOI: 10.1111/j.1440-1681.2009.05165.x

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