Hypoxia-inducible factor 1 and cardiovascular disease.

  title={Hypoxia-inducible factor 1 and cardiovascular disease.},
  author={Gregg L Semenza},
  journal={Annual review of physiology},
Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis… CONTINUE READING