Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions.

@article{Liu2015HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions.},
  author={Maoxi Liu and Kunli Du and Zhongxue Fu and Shouru Zhang and Xingye Wu},
  journal={Medical oncology},
  year={2015},
  volume={32 1},
  pages={394}
}
Hypoxia is a common characteristic of solid tumors. Recent studies confirmed that phospholipase D2 (PLD2) plays significant roles in cancer progression. In this study, correlation between the expression of PLD2 and the change in the protein level of hypoxia-inducible factor 1-alpha (HIF1-α) was studied. Thirty human colon cancer tissues were examined for the expression of HIF1-α and PLD2 protein, and mRNA levels. SW480 and SW620 cells were exposed to normoxia (20 %) or hypoxia (<1 %). HIF1… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Hypoxia response proteins HIF1-alpha, CAIX and GLUT1 as potential prognostic biomarkers in colorectal cancer

  • L Sansom, GGA Hutchins, M Shires, G Hemmings
  • J Pathol
  • 2012
1 Excerpt

Similar Papers

Loading similar papers…