Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells.

@article{Ryu2011HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells.},
  author={Kwanghee Ryu and Choa Park and Youngjoo Lee},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={407 4},
  pages={
          831-6
        }
}
The estrogen receptor is one of the most important transcription factors in breast tumor growth and development. We, and others, have previously shown that hypoxia induces rapid ERα protein degradation by a proteasome-mediated pathway in breast cancer cells, which is linked with ERα activation. However, no report has shown the effect of hypoxia on ESR1 gene regulation at the transcriptional level. In this report, we show that hypoxia repressed the expression of ERα mRNA in MCF-7 and T47D human… CONTINUE READING
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