Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide.

@article{Xueguan2008HypoxiaIF,
  title={Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide.},
  author={Lu Xueguan and Wang Xiaoshen and Zhang Yongsheng and Hu Chaosu and Shen Chunying and Feng Yan},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  year={2008},
  volume={20 8},
  pages={606-12}
}
AIMS Hypoxia reduces tumour radiosensitivity and hypoxia inducible factor-1 alpha (HIF-1 alpha) plays an important role in this process. The aim of the study was to assess the prognostic impact of HIF-1 alpha and vascular endothelial growth factor (VEGF) in patients with nasopharyngeal carcinoma who received radiation with hypoxia-modifying therapy (carbogen plus nicotinamide). MATERIALS AND METHODS The immunohistochemical expression of HIF-1 alpha and VEGF was evaluated in nasopharyngeal… CONTINUE READING
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