Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

@inproceedings{Schwab2011HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer},
  author={Luciana P. Schwab and Danielle L. Peacock and Debeshi Majumdar and Jesse F Ingels and L. C. W. Jensen and Keisha D Smith and Richard C Cushing and Tiffany N Seagroves},
  booktitle={Breast Cancer Research},
  year={2011}
}
Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The mouse mammary tumor virus polyoma virus middle T (MMTV-PyMT) mouse is a widely utilized preclinical mouse model that resembles human luminal breast cancer and is highly metastatic. Prior studies in which the PyMT model was used demonstrated that HIF-1α is essential to promoting carcinoma onset and lung metastasis, although no differences… CONTINUE READING