Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells.

@article{Fliesser2015HypoxiainducibleF1,
  title={Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells.},
  author={Mirjam Fliesser and Charles Oliver Morton and Michael Bonin and Frank Ebel and Kerstin H{\"u}nniger and Oliver Kurzai and Hermann Einsele and Juergen Loeffler},
  journal={International journal of medical microbiology : IJMM},
  year={2015},
  volume={305 8},
  pages={
          865-73
        }
}
The mold Aspergillus fumigatus causes life-threatening infections in immunocompromised patients. Over the past decade, new findings in research have improved our understanding of A. fumigatus-host interactions, including the recent identification of myeloid-expressed hypoxia-inducible factor 1α (HIF-1α) as a relevant immune-modulating transcription factor and potential therapeutic target in anti-fungal defense. However, the function of HIF-1α signaling for human anti-A. fumigatus immunity is… CONTINUE READING