Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment.

@article{Zhang2018HypoxiainducibleFS,
  title={Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment.},
  author={Jingying Zhang and Qi Zhang and Y B Lou and Qihan Fu and Qi Chen and Tao Wei and Jiaqi Yang and Jinlong Tang and Jianxin Wang and Y Grace Chen and Xiaoyu Zhang and Jian Zhang and Xueli Bai and Tingbo Liang},
  journal={Hepatology},
  year={2018},
  volume={67 5},
  pages={1872-1889}
}
The development and progression of hepatocellular carcinoma (HCC) are dependent on its local microenvironment. Hypoxia and inflammation are two critical factors that shape the HCC microenvironment; however, the interplay between the two factors and the involvement of cancer cells under such conditions remain poorly understood. We found that tumor-associated macrophages, the primary proinflammatory cells within tumors, secreted more interleukin 1β (IL-1β) under moderate hypoxic conditions due to… CONTINUE READING
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