Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions.

  title={Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions.},
  author={Ji-Won Lee and Seong-Hui Bae and J Jeong and Se-Hee Kim and Kyu-Won Kim},
  journal={Experimental & molecular medicine},
  volume={36 1},
Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha). The stability and activity of HIF-1alpha are regulated by various post-translational modifications, hydroxylation, acetylation, and phosphorylation. Therefore, HIF-1alpha interacts with several protein… CONTINUE READING


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