Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review).

  title={Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review).},
  author={Mikhail V. Blagosklonny},
  journal={International journal of oncology},
  volume={19 2},
Could a rational, hypothesis-driven and well-tolerated therapy drive tumor progression? This scenario can be foreseen for antiangiogenic therapy, despite it is one of the most elegant anticancer strategies. Antiangiogenic agents inhibit growth of endothelial cells resulting in tumor hypoxia and starvation which in turn inhibit tumor growth. On the other hand, it is known that hypoxia selects for a highly aggressive and metastatic cancer and is associated with unfavorable prognosis. This review… CONTINUE READING


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