Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression.

@article{Acs2003HypoxiainducibleES,
  title={Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression.},
  author={G{\'e}za Acs and Paul J Zhang and Cindy M McGrath and P{\'e}ter Acs and John W McBroom and Ahmed Mohyeldin and Suzhen Liu and Huasheng Lu and Ajay Verma},
  journal={The American journal of pathology},
  year={2003},
  volume={162 6},
  pages={1789-806}
}
Tissue hypoxia is a characteristic property of cervical cancers that makes tumors resistant to chemo- and radiation therapy. Erythropoietin (Epo) is a hypoxia-inducible stimulator of erythropoiesis. Acting via its receptor (EpoR), Epo up-regulates bcl-2 and inhibits apoptosis of erythroid cells and rescues neurons from hypoxic damage. In addition to human papillomavirus infection, increased bcl-2 expression and decreased apoptosis are thought to play a role in the progression of cervical… CONTINUE READING
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