Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release*

@inproceedings{Hatano2012HypoxiainducibleF,
  title={Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release*},
  author={Noriyuki Hatano and Yuka Itoh and Hiroka Suzuki and Yukiko Muraki and Hidetoshi Hayashi and Kikuo Onozaki and Ian C Wood and David J Beech and Katsuhiko Muraki},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca(2+))- and zinc (Zn(2+))-permeable ion channels that sense noxious substances. Despite the biological and clinical importance of TRPA1, there is little knowledge of the mechanisms that lead to transcriptional regulation of TRPA1 and of the functional role of transcriptionally induced TRPA1. Here we show induction of TRPA1 by inflammatory mediators and delineate the underlying molecular mechanisms and functional relevance. In… CONTINUE READING