Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.

@article{Zhang2016HypoxiaIT,
  title={Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.},
  author={Chuanzhao Zhang and Debangshu Samanta and Haiquan Lu and John W. Bullen and Huimin Zhang and Ivan Chen and Xiao-shun He and Gregg L Semenza},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 14},
  pages={E2047-56}
}
N(6)-methyladenosine (m(6)A) modification of mRNA plays a role in regulating embryonic stem cell pluripotency. However, the physiological signals that determine the balance between methylation and demethylation have not been described, nor have studies addressed the role of m(6)A in cancer stem cells. We report that exposure of breast cancer cells to… CONTINUE READING