Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body

@article{Yamamoto2006HypoxiaIP,
  title={Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body},
  author={Yoshio Yamamoto and Peter K{\"o}nig and Michael Henrich and J{\"u}rgen Dedio and Wolfgang Kummer},
  journal={Cell and Tissue Research},
  year={2006},
  volume={325},
  pages={3-11}
}
The carotid body is an arterial chemoreceptor organ that senses arterial pO2 and pH. Previous studies have indicated that both reactive oxygen species (ROS) and nitric oxide (NO) are important potential mediators that may be involved in the response of the carotid body to hypoxia. However, whether their production by the chemosensitive elements of the carotid body is indeed oxygen-dependent is currently unclear. Thus, we have investigated their production under normoxic (20% O2) and hypoxic (1… CONTINUE READING

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+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction

  • Y Yamamoto, M Henrich, RL Snipes, W Kummer
  • Proc Natl Acad Sci USA
  • 2003
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