Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes.

@article{Hinton2006HypoxiaIH,
  title={Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes.},
  author={Martha Hinton and Lynne Mellow and Andrew J Halayko and Alexey Gutsol and Shyamala Dakshinamurti},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={290 2},
  pages={L375-84}
}
PPHN, caused by perinatal hypoxia or inflammation, is characterized by an increased thromboxane-prostacyclin ratio and pulmonary vasoconstriction. We examined effects of hypoxia on myocyte thromboxane responsiveness. Myocytes from 3rd-6th generation pulmonary arteries of newborn piglets were grown to confluence and synchronized in contractile phenotype by serum deprivation. On the final 3 days of culture, myocytes were exposed to 10% O2 for 3 days; control myocytes from normoxic piglets were… CONTINUE READING

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