Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide.

@article{Barsoum2011HypoxiaIE,
  title={Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide.},
  author={Ivraym B. Barsoum and Thomas K. Hamilton and Xin Li and Tiziana Cotechini and Ellen A Miles and D. Robert Siemens and Charles H. Graham},
  journal={Cancer research},
  year={2011},
  volume={71 24},
  pages={7433-41}
}
One key to malignant progression is the acquired ability of tumor cells to escape immune-mediated lysis. Whereas tumor hypoxia is known to play a causal role in cancer metastasis and resistance to therapy, the link between hypoxia and immune escape in cancer remains poorly understood. Here, we show that hypoxia induces tumor cell resistance to lysis mediated by immune effectors and that this resistance to lysis occurs via a hypoxia-inducible factor-1 (HIF-1)-dependent pathway linked to… CONTINUE READING
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Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM 10 : role of nitric oxide

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  • Cancer Res
  • 2011

Themembrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHCclass I chain-relatedmolecule A independent of A disintegrin and metalloproteinases

  • LiuG, AtteridgeCL, WangX, LundgrenAD, WuJD
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