Hypoxia induces differential changes of dopamine metabolism in mature and immature mesencephalic and diencephalic cell cultures

@article{Gao1999HypoxiaID,
  title={Hypoxia induces differential changes of dopamine metabolism in mature and immature mesencephalic and diencephalic cell cultures},
  author={Ju Gao and Johann Gross and Nadezhda Andreeva and E. Glatzel and Hella Gruetzmann and Julia Heldt and Bernward Husemann and L. Jamielson and Kurt Gerok Andersson},
  journal={Journal of Neural Transmission},
  year={1999},
  volume={106},
  pages={111-122}
}
Perinatal hypoxia is known as a high risk factor for the development of long-lasting abnormalities in dopaminergic system. The early developmental alterations of dopamine (DA) metabolism induced by hypoxia could contribute to these abnormalities. To understand the hypoxia-induced changes of intra- and extracellular dopamine levels and its main metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in immature dopaminergic neurons, we compared these changes in rat… CONTINUE READING

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3 Excerpts

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