Hypoxia induces autophagy in primary human trophoblasts.

@article{Chen2012HypoxiaIA,
  title={Hypoxia induces autophagy in primary human trophoblasts.},
  author={Baosheng Chen and Mark S. Longtine and David M. Q. Nelson},
  journal={Endocrinology},
  year={2012},
  volume={153 10},
  pages={4946-54}
}
Autophagy is a highly regulated and dynamic process that maintains cellular homeostasis and plays a prosurvival role in most cells. Although hypoxia has been shown to induce apoptosis in placental trophoblasts, the hypoxic effect on autophagy has not been studied. We hypothesized that autophagy plays a prosurvival role in the placental trophoblasts by antagonizing hypoxia-induced apoptosis. Our data show that the expression of Light chain 3-II (LC3-II), an autophagic marker and cleaved poly(ADP… CONTINUE READING

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